Kratom News
Science, Trends & Strains

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Latest kratom science news

Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats.
Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats.
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Dr. Chris Mccurdy’s Lecture About Kratom Effects And Potential Positive Medical Benefits
Watch here leading research scientist Dr. Chris McCurdy’s eye-opening lecture about Kratom effects and potential positive medical benefits.
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Kratom may be effective to treat alcohol abuse disorder but still needs more studies.
Legislators across the USA continue to debate the safety of kratom, an opioid mimicking plant that has been noted as a "drug of issue" by the U.S."
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More than 1,000 times safer than opioids! Leading researcher Dr. Henningfield explains the exciting new science about Kratom.
On October 30, 2019, the Senate Committee on Health and Human Services held an executive sessionfollowed by an informational hearingon items relating to certificates to practice respiratory care, emergency medical services programs, and Kratom - a natural plant native to Southeast Asia - should be considered a controlled substance
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Keep up to date with current research and information about Kratom from the College of Pharmacy, University of Florida.
The information provided here is gathered from a range of scientific sources which have been reviewed by a team of experts. We strive to keep the
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Review of Eggleston et al. 2019 brief report, “Kratom Use and Toxicities in the United States”
Eggleston et al. published a brief report summarizing selected findings from calls to the US National Poison Control Data System (NPDS) from
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Current perspectives on the impact of Kratom use
Kratom has and is being used for the mitigation of opioid withdrawal symptoms and as a harm reduction agent with a minority of users subsequently developing a dependence on the extract.
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Kratom's reputed pain-relief benefits could come from one of its metabolites.
Kratom is a Southeast Asian tree with a long history of use in traditional medicine. In the region, the plant's leaves are widely consumed for pain relief, treatment of opioid addiction and other uses
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Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine
Dr. Scott Hemby, chair of basic pharmaceutical sciences in the Fred Wilson School of Pharmacy at High Point University, led and published a new study about kratom
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Recent research shows that Mitragynine the most predominant alkaloid in Kratom does not show abuse potential compared to 7-Hydroxymitragynine that does.
A very interesting research article about the abuse potential of Kratom. Top US addiction specialists and researchers have determined that..
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Mitragynine / Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit ß-Arrestin-2
Natural products found in Mitragyna speciosa, commonly known as kratom, represent diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl)
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CONCLUSIONS : These findings revealed that the medicinal and nutitional values of mitragynine obtained from Kratom leaves could be a promising antioxidant and anticancer or chemopreventive compound
It's quite complex but read the research here.
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Chemistry and Pharmacology of Analgesic Indole Alkaloids from the Rubiaceous Plant, Mitragyna speciosa
This is a well read journal from a scientist well known for his studies on Mitragyna speciosa and it's main alkaloids. One of the interesting things
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Two United States Patents relating to Kratom Extract and specific alkaloids.
Kratom (Milragynia speciosa korth) is recognized increasingly as a remedy for opioid Withdrawal by individuals Who self-treat chronic pain and/or
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The informal use of Kratom (Mitragyna speciosa) for opioid withdrawal in the northern states of peninsular Malaysia and implications for drug substitution therapy
Two United States Patents relating to Kratom Extract and specific alkaloids.
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Pharmacology of Kratom: An Emerging Botanical Agent With Stimulant, Analgesic and Opioid-Like Effects
From the Department of Pharmacology at the Midwestern University/Chicago
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Pharmacological Studies on 7-Hydroxymitragynine, Isolated from the Thai Herbal Medicine Mitragyna speciosa: Discovery of an Orally Active Opioid Analgesic
This journal speaks for itself. Anyhow interested in Kratom's main alkaloids Mitragynine and 7-Hydroxymitragynine will find this interesting and a
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Neurobiology of Kratom and its main alkaloid Mitragynine.
Author: Farah W. Suhaimi Nurul H.M. Yusoff Rahimah
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Opioid receptor agonistic characteristics of mitragynine pseudoindoxyl in comparison with mitragynine derived from Thai medicinal plant Mitragyna speciosa
Mitragynine pseudoindoxyl is an alkaloid synthesized from Mitragynine. It is also much stronger than Mitragynine but does not occure naturally in
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MITRAGYNA SPECIOSA: AN ANALYTICAL STUDY
Another analytical study done on Kratom use this time in the US. An analysis was also done on commercial available Kratom products such as VivaZen
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A Collective Analysis from the United Kratom Association
A consumer-focused survey collected 466 individual’s responses that represent a high-functioning and well-educated group who, through the responsible
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Kratom (Mitragyna speciosa) dependence, withdrawal symptoms and craving in regular users
A study done in Malaysia in 2014 by the Centre for Drug Research at the Science University of Malaysia. The journal is easy to read and provides lots
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An analysis of Mitragynine & 7-Hydroxymitragynine in commercial Kratom products.
A very interesting study pubished by Japanese Association of Forensic Toxology. The study concludes that the commercial Kratom products that they
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Following “the Roots” of Kratom
Read the journal
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Experiences of Kratom Users: A Qualitative Analysis
A collection of bioassay reports looking at effects of Kratom on its users..
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Dose–Response Relationship, Acute Toxicity, and Therapeutic Index between the Alkaloid Extract of Mitragyna speciosa and Its Main Active Compound Mitragynine in Mice
Here is a very interesting research paper that shows how as an individual substance, pure Mitragynine is seen to be even safer than plain leaf!!
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Comparison of the mitragynine content of aqueous extracts from Mitragyna speciosa Korth leaves from two different geographic areas in Malaysia
Here is a very interesting research paper that shows how as an individual substance, pure Mitragynine is seen to be even safer than plain leaf!!
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Comparison of Three Chromatographic Techniques for the Detection of Mitragynine and other Indole and Oxindole Alkaloids in Mitragyna speciosa (Kratom) Plants
An interesting article showing a comparison of three chromatographic techniques for the detection of mitragynine and other indole and oxindole alkaloids in Mitragyna speciosa.
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Acute Toxicity Study of Standardized Mitragyna speciosa Korth Aqueous Extract in Sprague Dawley Rats
This study looks into toxicity of Kratom and is Mitrgynine based extractions.
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The effects on motor behaviour and short-term memory tasks in mice following an acute administration of Mitragyna speciosa alkaloid extract and mitragynine
This study investigates the effects of the alkaloid extract of Mitragyna speciosa leaves
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Testimonies of responsible Kratom users as compiled by the American Kratom Association between September 19th and September 21st 2016
Testimonies of Kratom consumbers as compiled by the American Kratom Association.
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Social Functioning of Kratom (Mitragyna speciosa) Users in Malaysia
Kratom users do not experience major impairments in their social functioning, despite being dependent on kratom for prolonged periods.
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Self-Treatment of Opioid Withdrawal with a Dietary Supplement, Kratom
This journal examins the use of Kratom (Mitragyna speciosa), a dietary supplement with mu-opioid agonist activity, by members of a cybercommunity who self-treat chronic pain with opioid analgesics from Internet pharmacies
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Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth)
Kratom (Mitragynia speciosa korth) is recognized increasingly as a remedy for opioid withdrawal by individuals who self-treat chronic pain
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Kratom by Murple
Kratom is a psychoactive tree indiginous to Southeast Asia. Commonly written in English as kratom,
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Herbal Medicines for the Management of Opioid Addiction
Striking increases in the abuse of opioids have expanded the need for pharmacotherapeutic interventions
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Factor Analytical Investigation of Krathom (Mitragyna speciosa Korth.) Withdrawal Syndrome in Thailand
This is a study about kratom withdrawal symptoms of two groups of 196 and 330 kratom users in rural Thailand aged over 25 years old
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Experiences of Kratom Users: A Qualitative Analysis
A qualitative analysis of first-hand descriptions of recent human kratom users that were submitted to information website (Erowid.org)
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The Combination of Mitragynine and Morphine Prevents the Development of Morphine Tolerance in Mice
A research paper showing that the combinational treatment of Mitragynine and Morphine prevents Morphone tolerence in mice.
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Following (the Roots) of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries
The use of substances to enhance human abilities is a constant and cross-cultural feature in the evolution of humanity.
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An Insight into the Effect of Mitragyna speciosa Korth Extract on Various Systems of the Body
A study by the Department of Anatomy, Faculty of Medicine Universiti Kebangsaan Malaysia on the effects that Mitragyna speciosa extract has on various bodily functions such as central nervous system, gastrointestinal system and urinary system.
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From Kratom to mitragynine and its derivatives: Physiological and behavioural effects related to use, abuse, and addiction
Here we reviewed the available evidence and identified future research needs.
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Evaluation of Antioxidant and Antibacterial Activities of Aqueous, Methanolic and Alkaloid Extracts from Mitragyna Speciosa (Rubiaceae Family) Leaves
Studies on the antioxidant and antimicrobial activities of Mitragyna speciosa leaf extracts are lacking. In this study the antioxidant properties of water, methanolic and alkaloid M. speciosa leaf extracts were evaluated.
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Mitragyna Speciosa : An analytical study
Legal highs are compounds that produce the same psychoactive effects as illicit compounds, but are not legally controlled under the Controlled Substances Act.
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Chemistry and Pharmacology of Analgesic Indole Alkaloids from the Rubiaceous Plant, Mitragyna speciosa
The leaves of a tropical plant, Mitragyna speciosa KORTH (Rubiaceae), have been traditionally used as a sub- stitute for opium
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Kratom (Mitragyna speciosa) dependence, withdrawal symptoms and craving in regular users
The Use of Kratom in traditional Malaysia. This study is the first to measure systematically Kratom dependence, withdrawal symptoms, and drug craving in regular Kratom users in Malaysia.
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